Preparation of indole derivatives

专利名称：Preparation of indole derivatives发明人：Shigeaki Morooka,Katsumi Tamoto,Akira

Matuura

申请号：US05/691777申请日：19760601公开号：US04069230A公开日：19780117

摘要：An improved process for preparing indole derivatives of the formula, ##STR1##wherein R.sub.1 and R.sub.2 each are hydrogen, halogen, C.sub.1 - C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, nitro, cyano or trifluoromethyl, or when taken together, formmethylenedioxy; R.sub.3 is hydrogen, halogen, C. sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3alkoxy, nitro, cyano or dimethylamino; and R.sub.4 is hydrogen or halogen, whichcomprises cyclizing a compound of the formula, ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined above, with an acidic condensing agent.

The indole derivatives of the formula (I) mentioned above are useful as a keyintermediate for the preparation of benzodiazepines, which are useful as tranquilizers,muscle relaxants and the like.

申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

代理机构：Stevens, Davis, Miller & Mosher

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